Chemical key to cell division revealed

In each of our cells, most of the genetic material is packaged safely within the nucleus, which is protected by a double membrane. The biochemistry behind how this membrane transforms when cells divide has finally been unravelled, offering insights that could provide new ways of fighting cancer and some rare genetic disorders.

During cell division, the membrane that surrounds the nucleus breaks down and reforms in the two daughter cells. Researchers have been split on the precise mechanisms that govern membrane reformation. One view is that proteins alone control the membrane's transformations. Another possibility is that changes in lipids – a vast group of fat-related compounds – are responsible.

Experiments had failed to show which of these two ideas was right, because it was difficult to alter lipid levels in specific compartments of cells without affecting other cellular processes.

Banafshe Larijani at Cancer Research UK's London Research Institute and her colleagues have now overcome that hurdle. They came up with a technique that transforms a type of lipid called a diacylglycerol (DAG) into another lipid, within the nuclear membrane.

Chemical cascade

The technique involves inserting two fragments of DNA into the nucleus of a cell. This causes the cell to make two proteins: the first attaches itself to the nuclear membrane, the second floats around the cell. Adding a drug – rapalogue – to the mix causes the second protein to stick to the first, which in turn causes a chemical cascade that transforms the DAG into a different kind of lipid.

Crucially, they targeted a form of DAG that does not bind to proteins, so converting it into a different lipid does not affect any processes involving proteins in the cell.

The team tested the effect of this lipid manipulation on cell division in monkey and human cancer cells. The lower the level of DAG present in the nuclear membrane, the greater the membrane malformation and chance of cell death.

This demonstrates that lipids play a role in nuclear membrane reformation that does not depend on proteins.

Larijani says it "opens the door to finding ways to kill cancerous cells" by focusing on lipids that are important to the nuclear membrane's development.

Sausage pieces

As the nucleus divides, sausage-shaped fragments of its membrane float around the cell. The fragments have curved ends, and Larijani says that changes in lipid composition generate these curves, without which the fragments cannot reassemble correctly into new membranes.

More than a dozen rare genetic conditions such as Hutchinson-Gilford progeria syndrome, which is characterised by premature ageing in children, have been linked to irregularities in cell division. A better understanding of the way the nuclear membrane forms when cells divide could be key to treating these disorders.

The research also offers a new focus for preventing the irregular cell division that underlies many cancers.

"As a result of this work we now know with confidence that DAG plays a structural role in membrane dynamics," says Vytas Bankaitis, at the Texas A&M Health Science Center in College Station, who was not involved in the study. "If we could find a molecule with suitable characteristics, this manipulation could be done [in humans], which is something that has not really been considered before."

Journal reference: PLoS ONE DOI: 10.1371/journal.pone.0051150

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Critics give epic 'Hobbit' middle marks

NEW YORK: Peter Jackson's "The Hobbit: An Unexpected Journey" opens in the US this month and critics say the movie, much like the epic journey it depicts, is adventurous - but an uphill slog.

The fantasy about a Hobbit called Bilbo Baggins, Gandalf the good wizard, 13 raucous dwarves, and a host of evil forces, takes viewers back to the lavishly filmed Middle-earth world that won Oscars and rave reviews in Jackson's previous "Lord of the Rings" trilogy.

But reviews from journalists, who got to see the nearly three-hour movie ahead of its December 14 US premiere, were also somewhere in the middle.

Jackson's technical wizardry, using 3D and 48 frames a second, rather than the ordinary 24 frames, got gasps of admiration, mixed with yawns about overkill.

And while the New Zealand-born director scored high marks for the faithfulness of the adaption from J.R.R. Tolkien's book, there was incredulity - and some cynicism - about the decision to split the relatively slender "Hobbit" into three enormous movies.

"In Jackson's academically fastidious telling, however, it's as if 'The Wizard of Oz' had taken nearly an hour just to get out of Kansas," The Hollywood Reporter said in a bruising review.

"There are elements in this new film that are as spectacular as much of the Rings trilogy was, but there is much that is flat-footed and tedious as well."

Variety's critic took aim at the overwhelming detail poured into 48-frames-a-second pictures.

"Everything takes on an overblown, artificial quality in which the phoniness of the sets and costumes becomes obvious, while well-lit areas bleed into their surroundings, like watching a high-end home movie," Variety said.

"The Hobbit", which was screened for journalists in New York on Tuesday, is a prequel to the darker "Lord of the Rings," introducing the main characters and plot lines that reappear through the entire saga. The cursed golden ring also makes its first appearance.

There are bravura battle scenes, choreographed hordes of Goblins, fantastical caves, and James Bond-style narrow escapes from death for Martin Freeman's Bilbo Baggins and his dwarf friends. As in the three "Rings" movies, the natural settings of New Zealand are breath-taking.

But with so many strange beings attacking each other with swords, and so many arrows, rocks and bodies flying in 3D at the audience, the few intimately staged scenes focusing on just a couple characters can come as a relief.

When the action cut suddenly from the latest mass sword fight to a silent cave inhabited by Andy Serkis' creepy character Gollum, journalists at Tuesday's press screening broke out in a rare smattering of applause.

Jackson defended the decision to stretch the book to three movies, in contrast to the "Rings" trilogy, which was based on three books.

He told reporters Wednesday in New York that in Tolkien's often "breathless" text, "very major events are covered in two or three pages," and that transferring the action to film required a more sumptuous treatment.

Screenwriter and co-producer Philippa Boyens said the different pace responded to the dynamics of working with actors.

"Great actors come to you for the material and if you give them very slight material, you're just not going to get them. We wanted to write for these great actors," she said.

The filmmakers also defended their use of the 48 frames a second. "Fantasy should be as real as possible," Jackson said, "The levels of detail are very important."

The reviews for "The Hobbit" were far from universally negative, and many critics said the three films may well make healthy profits. On the reviews aggregator website Rotten Tomatoes, the rating of fresh versus rotten tomatoes was a high 78 percent Wednesday.

Great British actor Ian McKellen, who reprised his "Rings" role as Gandalf in "The Hobbit", batted down suggestions that the filmmakers were trying to milk the maximum profit out of Tolkien fans.

"Anyone who thinks Peter Jackson would fall for market forces, instead of artistic imperatives, just doesn't know him, doesn't know the body of his work," McKellen told reporters.

The movies will do well because Bilbo Baggins and his travails are a universal story, he said.

"It's about the little guy that we need and may be expendable, who may not come back."

-AFP/fl

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Blockbuster said to sell smartphones at its retail stores

Blockbuster is rumored to be getting ready to sell mobile phones at its retail stores.

(Credit:
Blockbuster)

When DVD rentals don't work, maybe sell... mobile phones? Rumor has it that Blockbuster is getting into the phone hawking business at its retail stores, according to Bloomberg.

What seems like a random choice might actually be a conscientious maneuver by Dish Network, which bought the struggling movie rental chain last year. Dish is primarily a provider of satellite-TV service, but over the past year it's been making moves to get into the wireless business.

Recently, Dish launched Blockbuster Mobile and started selling smartphones online. Blockbuster Mobile works with Sprint, T-Mobile, and Verizon and offers devices including Samsung's Galaxy S3. Selling these phones in brick-and-mortar stores seems like a decent guess for Dish's next step.

After Dish bought Blockbuster, for $320 million, Dish said it planned to keep 1,500 Blockbuster rental stores open and maintain 15,000 employees. However, after hundreds of stores slipped into the red, the company ended up keeping open only about 850 locations. Bloomberg reports that mobile-phone sales are said to be planned for all of the stores that stayed open.

According to Bloomberg, Dish may be heading toward offering its own mobile service. It apparently has bought some wireless airwaves and is waiting to hear back from the Federal Communications Commission about how it will be allowed to use them. Last month Dish said U.S. regulators wouldn't grant immediate approval for its own service, but perhaps now the process is moving along.

"Wireless will complement all of our technologies and allow us to be in more places and offer more of our services on one bill," Dish chairman and co-founder Charlie Ergen told Bloomberg in October.

Both Dish and Blockbuster declined to comment on whether the DVD rental chain will begin selling mobile phones at its stores.

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A 2020 Rover Return to Mars?

NASA is so delighted with Curiosity's Mars mission that the agency wants to do it all again in 2020, with the possibility of identifying and storing some rocks for a future sample return to Earth.

The formal announcement, made at the American Geophysical Union's annual fall meeting, represents a triumph for the NASA Mars program, which had fallen on hard times due to steep budget cuts. But NASA associate administrator for science John Grunsfeld said that the agency has the funds to build and operate a second Curiosity-style rover, largely because it has a lot of spare parts and an engineering and science team that knows how to develop a follow-on expedition.

"The new science rover builds off the tremendous success from Curiosity and will have new instruments," Grunsfeld said. Curiosity II is projected to cost $1.5 billion—compared with the $2.5 billion price tag for the rover now on Mars—and will require congressional approval.

While the 2020 rover will have the same one-ton chassis as Curiosity—and could use the same sky crane technology involved in the "seven minutes of terror"—it will have different instruments and, many hope, the capacity to cache a Mars rock for later pickup and delivery to researchers on Earth. Curiosity and the other Mars rovers, satellites, and probes have garnered substantial knowledge about the Red Planet in recent decades, but planetary scientists say no Mars-based investigations can be nearly as instructive as studying a sample in person here on Earth.

(Video: Mars Rover's "Seven Minutes of Terror.")

Return to Sender

That's why "sample return" has topped several comprehensive reviews of what NASA should focus on for the next decade regarding Mars.

"There is absolutely no doubt that this rover has the capability to collect and cache a suite of magnificent samples," said astronomer Steven Squyres, with Cornell University in New York, who led a "decadal survey" of what scientists want to see happen in the field of planetary science in the years ahead. "We have a proven system now for landing a substantial payload on Mars, and that's what we need to enable sample return."

The decision about whether the second rover will be able to collect and "cache" a sample will be up to a "science definition team" that will meet in the years ahead to weigh the pros and cons of focusing the rover's activity on that task.  

As currently imagined, bringing a rock sample back to Earth would require three missions: one to select, pick up, and store the sample; a second to pick it up and fly it into a Mars orbit; and a third to take it from Mars back to Earth.

"A sample return would rely on all the Mars missions before it," said Scott Hubbard, formerly NASA's "Mars Czar," who is now at Stanford University. "Finding the right rocks from the right areas, and then being able to get there, involves science and technology we've learned over the decades."

Renewed Interest

Clearly, Curiosity's success has changed the thinking about Mars exploration, said Hubbard. He was a vocal critic of the Obama Administration's decision earlier this year to cut back on the Mars program as part of agency belt-tightening but now is "delighted" by this renewed initiative.

(Explore an interactive time line of Mars exploration in National Geographic magazine.)

More than 50 million people watched NASA coverage of Curiosity's landing and cheered the rover's success, Hubbard said. If things had turned out differently with Curiosity, "we'd be having a very different conversation about the Mars program now."

(See "Curiosity Landing on Mars Greeted With Whoops and Tears of Jubilation.")

If Congress gives the green light, the 2020 rover would be the only $1 billion-plus "flagship" mission—NASA's largest and most expensive class of projects—in the agency's planetary division in the next decade. There are many other less ambitious projects to other planets, asteroids, moons, and comets in the works, but none are flagships. That has left some planetary scientists not involved with Mars unhappy with NASA's heavy Martian focus.

Future Plans

While the announcement of the 2020 rover mission set the Mars community abuzz, NASA also outlined a series of smaller missions that will precede it. The MAVEN spacecraft, set to launch next year, will study the Martian atmosphere in unprecedented detail; a lander planned for 2018 will study the Red Planet's crust and interior; and NASA will renew its promise to participate in a European life-detection mission in 2018. NASA had signed an agreement in 2009 to partner with the European Space Agency on that mission but had to back out earlier this year because of budget constraints.

NASA said that a request for proposals would go out soon, soliciting ideas about science instruments that might be on the rover. And as for a sample return system, at this stage all that's required is the ability to identify good samples, collect them, and then store them inside the rover.

"They can wait there on Mars for some time as we figure out how to pick them up," Squyres said. "After all, they're rocks."

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Bodies Found in Hunt for Missing Iowa Cousins

Nearly five months after Iowa cousins Lyric Cook and Elizabeth Collins disappeared, the girls' families have been told two bodies were found by hunters in a wooded area, though the identities of the bodies have not been confirmed, authorities said.

Capt. Rick Abben of the Black Hawk County Sheriff's Office said at a press conference this afternoon that the bodies are being transported to the state's medical office in Ankeny, Iowa, for positive identification.

"It's definitely not the outcome that we wanted, obviously," Abben said. "This is a difficult thing for us to go through."

Lyric, 11, and Elizabeth , 9, vanished shortly after noon on July 13 while on a bike ride in the small town of Evansdale, Iowa, triggering a massive search that brought the town to a standstill. The girls' bicycles and a purse were quickly found near Meyers Lake, but there was no sign of the girls.

PHOTOS From ABC News Affiliate KCRG: The Search for Lyric & Elizabeth

Black Hawk County Police/AP Photo

Missing Iowa Girls Seen Riding Bikes on Surveillance Video Watch Video

Missing Iowa Girls: One Mother Takes 2nd Polygraph Watch Video

On the two-month anniversary of the girls' disappearance, local residents held a prayer vigil and authorities urged members of the public to provide any new information that might help them solve the case.

Authorities said the girls left Elizabeth's house in Evansdale around 12:15 p.m., were spotted at approximately 12:23 p.m. at a nearby intersection and then were seen between 12:30 and 1 p.m. on a road by the lake.

During the following week, authorities canvassed the area and drained the town's lake. Lyric's estranged parents, Misty and Dan Morrissey, at one point became the subject of intense police scrutiny because of their criminal pasts and their lack of cooperation.

Over the summer, the families received a boost when Elizabeth Smart, one of the country's most famous kidnapping survivors, offered some words of encouragement. Police found Smart after a nine-month search in Utah a decade ago.

"For as many bad things that we hear about that happen, for as many kidnappings and terrible stories about finding the remains of children, why can't these girls be the exception?" Smart told the Des Moines Register.

Elizabeth's mother, Heather Collins, told ABC News' Alex Perez in July that the wait for the girls to reappear was an agonizing one.

"A day doesn't seem like a normal day," Collins said. "It's just like it doesn't stop. It keeps dragging and dragging. You're just waiting for a time to go up to your room. You're just waiting, waiting, waiting."

"Whoever's out there, we're just begging you to bring our girls back home," she said.

A $50,000 reward had been offered for information that led to the arrest and conviction of the person responsible for the girls' disappearance.

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When is a baby too premature to save?

It was never easy, but trying to decide whether to save extremely premature babies just got harder.

A study called EPICure compared the fates of babies born 22 to 26 weeks into pregnancy in the UK in 1995 with similar babies born in 2006. In this 11-year period, the babies surviving their first week rose from 40 to 53 per cent. But an accompanying study comparing the fate of survivors at age 3 found that the proportion developing severe disabilities was unchanged, at just under 1 in 5.

"We've increased survival, but it's confined to the first week of life," says Kate Costeloe of Queen Mary, University of London, author of the first study. "Yet the pattern of death and health problems is strikingly similar between the two periods."

The absolute numbers of premature babies born over the 11 year period increased by 44 per cent, from 666 in 1995 to 959 in 2006. This meant that the absolute numbers of children with severe disabilities such as blindness, deafness or lameness also rose, increasing the burden on health, educational and social services.

Lifelong disability

"As the number of children that survive preterm birth continues to rise, so will the number who experience disability throughout their lives," says Neil Marlow of University College London, who led the second study.

By far the worst outcomes were for the youngest babies, with 45 per cent of those born at 22 or 23 weeks in 2006 developing disabilities compared with 20 per cent of those born at 26 weeks. In 1995 only two babies survived after being born at 22 weeks. In 2006, three did.

In 2006, a panel of UK ethicists concluded that babies born at 22 weeks should be allowed to die, as with babies born at or before 23 weeks in France and Holland.

Journal references: BMJ, Costeloe et al, DOI: 10.1136/bmj.e7976; Marlow et al, DOI: 10.1136/bmj.e7961

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Britain braces for key budget update

LONDON: British finance minister George Osborne unveils his budget update on Wednesday, and will likely admit it could take longer than expected to slash the deficit as a result of the weaker-than-expected economy.

Chancellor of the Exchequer Osborne was to deliver his Autumn Statement before parliament at 1230 GMT, when the Office for Budget Responsibility (OBR) fiscal watchdog will also publish its latest growth and borrowing forecasts.

Osborne has already warned that economic recovery will take longer than hoped but insisted that abandoning the government's tough deficit-slashing austerity measures would be catastrophic amid the ongoing eurozone debt crisis.

"We had two targets, one was to get debt share falling as a share of national income by 2015/16 and also to balance the current budget," the chancellor told BBC television over the weekend.

"It's clearly taking longer to deal with Britain's debts; it's clearly taking longer to recover from the financial crisis than anyone would have hoped but we have made real progress."

Ahead of the budget update, Osborne pledged Tuesday to invest £5.0 billion in schools, transport and science over the next two fiscal years, with the cash sourced from a new raft of spending cuts across most civil service departments.

And on Monday, Osborne launched a campaign against "tax dodgers" and "cowboy advisers" to claw back £2.0 billion a year, as lawmakers alleged that multinationals such as Starbucks and Google are avoiding huge tax bills.

The OBR was meanwhile expected to lower its gross domestic product (GDP) forecasts as the economy faces major headwinds from state austerity, inflationary pressures and the eurozone's ongoing crisis.

Osborne had in March forecast that the British economy would grow by 0.8 per cent this year, followed by 2.0 per cent in 2013 and 2.7 per cent in 2014.

Weaker economic growth would slash taxation receipts and spark upward revisions to its official borrowing targets, according to analysts.

Alongside Osborne's budget in March, the OBR predicted that public sector net borrowing (PSNB) as a proportion of economic output would begin to fall in 2015/2016, after peaking at 76.3 per cent of GDP in 2014/15.

And it forecast state borrowing would reach £120 billion ($192 billion, 148 billion euros) in the 2012/2013 financial year ending in March, compared with £121.4 billion in 2011/2012.

But with PSNB already standing at £73.3 billion and four months of the financial year to go, Osborne could breach the target.

Recent official data showed Britain had escaped from recession in the third quarter of this year, with its economy growing 1.0 per cent.

However, experts argue this was due to one-off factors like the London Olympics and rebounding activity after public holidays in the second quarter.

The Conservative-Liberal Democrat coalition government imposed austerity measures to slash a record deficit inherited from the previous Labour administration. Opposition Labour politicians maintain that the cuts pushed the economy into a painful double-dip recession.

The Organisation for Economic Co-operation and Development urged Osborne last week to push back his debt reduction targets rather than drive through more growth-damaging austerity.

Meanwhile, the country's official statistics watchdog on Tuesday warned the government to stop claiming that real-terms National Health Service spending had increased after calculating funds had actually fallen slightly.

The UK Statistics Authority said Health Secretary Jeremy Hunt should "clarify" claims on the Conservative party website that "we have increased the NHS budget in real terms in each of the last two years".

- AFP/ck

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Apple sacks two-per-customer rule for iPhone 5

Apple's iPhone 5.

(Credit:
CNET)

The "limit two per customer" rule became conspicuously absent from the iPhone 5 order form on Apple's Web store today.

It seems that supply has finally met up with demand and the tech giant is letting people order the device willy-nilly.

Not only has the two-per-customer limit been removed, but the 10-phone per lifetime limit has also been lifted, according to MacRumors. Now, MacRumors reports, customers are limited to ten devices for each transaction and no lifetime limit.

Apple started selling unlocked iPhone 5 smartphones last week, which frees users from being tethered to a network. Users can instead insert a nano-SIM card from any supported carrier into the smartphone and it will be ready for use anywhere around the world.

It's likely that many of the customers who will be buying the
iPhone 5 in bulk are resellers who ship the device overseas where it isn't yet offered. However, it's looking like Apple is getting a grip on that market too. The company announced yesterday that the iPhone 5 would be available in South Korea on Friday and more than 50 additional countries will be getting the smartphone later this month.

Apple has been struggling with supply chain issues since the iPhone 5 first launched in September. It seems that it's now finally under control. As of today, ship times in the U.S. have gone from nearly a month-long delay to only a two-to-four day wait time.

CNET contacted Apple for comment. We'll update the story when we get more information.

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Scientific Results From Challenger Deep

Jane J. Lee

The spotlight is shining once again on the deepest ecosystems in the ocean—Challenger Deep in the Mariana Trench (map) and the New Britain Trench near Papua New Guinea. At a presentation today at the American Geophysical Union's conference in San Francisco, attendees got a glimpse into these mysterious ecosystems nearly 7 miles (11 kilometers) down, the former visited by filmmaker James Cameron during a historic dive earlier this year.

Microbiologist Douglas Bartlett with the University of California, San Diego described crustaceans called amphipods—oceanic cousins to pill bugs—that were collected from the New Britain Trench and grow to enormous sizes five miles (eight kilometers) down. Normally less than an inch (one to two centimeters) long in other deep-sea areas, the amphipods collected on the expedition measured 7 inches (17 centimeters). (Related: "Deep-Sea, Shrimp-like Creatures Survive by Eating Wood.")

Bartlett also noted that sea cucumbers, some of which may be new species, dominated many of the areas the team sampled in the New Britain Trench. The expedition visited this area before the dive to Challenger Deep.

Marine geologist Patricia Fryer with the University of Hawaii described some of the deepest seeps yet discovered. These seeps, where water heated by chemical reactions in the rocks percolates up through the seafloor and into the ocean, could offer hints of how life originated on Earth.

And astrobiologist Kevin Hand with the Jet Propulsion Laboratory in Pasadena, California, spoke about how life in these stygian ecosystems, powered by chemical reactions, could parallel the evolution of life on other planets.

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Tasting DNA-Altered Salmon That May Hit US Plates

Deep in the rain forests of Panama, in a secret location behind padlocked gates, barbed-wire fences and over a rickety wooden bridge, grows what could be the most debated food product of our time.

It may look like the 1993 hit movie "Jurassic Park," but at this real-life freshwater farm scientists are altering the genes not of dinosaurs -- but of fish.

They are growing a new DNA-altered saltwater fish in the mountains, far from the sea -- a salmon that could be the first genetically altered animal protein approved for the world to eat. If it is approved, this would be a landmark change for human food.

But it is one critics call "Frankenfish."

"The idea of changing an animal form, I think, is really creepy," said Gary Hirshberg, founder of Stonyfield Farm, an organic dairy farm. "When you move the DNA from a species into another species ... you create a new life form that's so new and so unique that you can get a patent for it."

And until now, AquaBounty, the multinational biotech company that for 20 years has been developing this giant fish, has kept it under close wraps.

The press has never been invited to its Prince Edward Island laboratory on the Canadian maritime coast, and its fish farm location in Panama has been kept secret out of fear of sabotage.

The Food and Drug Administration has seen it, but few from the outside. In fact, the last public tour of any kind was four years ago.

AquaBounty Creates 'Fort Knox for Fish'

ABC News was given exclusive access to see the facilities up close and an opportunity to taste this mysterious fish that FDA scientists say "is as safe as food from conventional Atlantic salmon," although have yet to officially approve it for public sale.

Ron Stotish, the president and CEO of AquaBounty Technologies, the company that created and hopes to market the eggs of this salmon to independent fish farms around the world, told ABC News it has employed bio-security measures, creating a "Fort Knox for fish," to ensure safety for the fish and prevent cross-contamination with the wild.

Entry to both facilities begins with body suits and iodine baths for shoes, which serves to keep the fish safe from germs.

Inside these protected tanks, America gets the first up-close look at the final product, the fish that has the food police up in arms.

"These are very healthy, beautiful Atlantic salmon," Stotish said.

With one big difference -- the growth rate of a regular salmon compared to that of an AquaBounty genetically modified fish.

While the AquaBounty fish do not grow to a size larger than normal salmon, they get to full size much faster, cutting costs for producers.

A normal-size 1-year-old Atlantic salmon averages 10 inches long, while the genetically modified fish at the same age is more than two times larger, coming in at 24 inches.

Salmon is the second most popular seafood in America. According to the National Oceanic and Atmospheric Administration, the average size of an Atlantic salmon is 28 inches to 30 inches and 8 pounds to 12 pounds after two years at sea.

How do they accomplish the accelerated growth?

"They differ by a single gene," Stotish said.

But, it's that single gene change that makes the DNA-altered salmon grow much faster than a normal Atlantic salmon, because it's really three fish in one.

AquaBounty scientists have taken a growth gene from the Chinook salmon and inserted it into the DNA of the Atlantic salmon because Chinooks grow fast from birth, while Atlantics do not.

"Salmon in their first two years of life grow very slowly," Stotish said.

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