Quadruple DNA helix discovered in human cells

Sixty years after James Watson and Francis Crick established that DNA forms a double helix, a quadruple-stranded DNA helix has turned up.

Quadruple helices that intertwine four, rather than two, DNA strands had been made in the laboratory, but were regarded as curiosities as there was no evidence that they existed in nature. Now, they have been identified in a range of human cancer cells.

The four-stranded packages of DNA, dubbed G-quadruplexes, are formed by the interaction of four guanine bases that together form a square. They appear to be transitory structures, and were most abundant when cells were poised to divide. They appeared in the core of chromosomes and also in telomeres, the caps on the tips of chromosomes that protect them from damage.

Because cancer cells divide so rapidly, and often have defects in their telomeres, the quadruple helix might be a feature unique to cancer cells. If so, any treatments that target them will not harm healthy cells.

"I hope our discovery challenges the dogma that we really understand DNA structure because Watson and Crick solved it in 1953," says Shankar Balasubramanian of the University of Cambridge, UK.

Tagged with antibodies

Balasubramanian's team identified the four-stranded structures in cancer cells with the help of an antibody that attaches exclusively to G-quadruplexes. To stop them from unravelling into the ordinary DNA, they exposed the cells to pyridostatin, a molecule that traps quadruple helices wherever they form.

This enabled the researchers to count how many formed at each stage of cell multiplication. The G-quadruplexes were most abundant in the "S-phase" – when cells replicate their DNA just prior to dividing.

"I expect they will also exist in normal cells, but I predict that there will be differences with cancer cells," says Balasubramanian. His hunch is that the G-quadruplexes are triggered into action by chaotic genomic mutations and reorganisations typical of cancerous or precancerous cells.

"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer, and the next part of this is to figure out how to target them in tumour cells," says Julie Sharp of Cancer Research UK, which funded the research.

Another important question that Balasubramanian's and other teams will try to answer is whether G-quadruplexes play a role in embryo development, and whether such a role is mistakenly reactivated in cancer cells. "We plan to find out whether the quaduplexes are a natural nuisance, or there by design," he says.

Journal reference: Nature Chemistry, DOI: 10.1038/NCHEM.1548

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

Read More..

SDA's Lim to launch online rally at 6pm

SINGAPORE: The Singapore Democratic Alliance's (SDA's) candidate for Punggol East, Mr Desmond Lim, will start his online rally at 6pm on Monday.

Mr Lim told reporters after meeting residents at Kangkar LRT Station in the morning that he will start with two video clips.

Each clip will be between seven and 10 minutes long.

Mr Lim said he will produce at least 10 clips during his by-election campaign.

The videos will be available on his Facebook page and can be downloaded to smartphones.

Mr Lim said his volunteers will approach residents during the walkabouts and ask them if they would like use Bluetooth to transfer the clips to their phones.

- CNA/al

Read More..

Where to watch Obama's inauguration online

President Obama was sworn in for his second term today in a quiet ceremony at the White House. But it was a simple prelude to the festivities that will take place tomorrow when Obama and Vice President Joe Biden are sworn in outside of the U.S. Capital before hundreds of thousands of spectators -- and countless more who will be tuning in online to watch the event.

The last presidential inauguration ceremony in 2009 was considered by many to be the most interactive ever. But thanks to multimedia content -- including the return of high-resolution satellite imagery from GeoEye -- we may see just as many innovative forms of coverage for this year's event, even though this one is expected to be more low-key.

The public swearing-in ceremony begins at 11:30 a.m. ET, with the official event happening at 11:55 a.m.

Here's just a partial list of where to tune in. Feel free to add to it in the comments below.

• The 2013 Presidential Inaugural Committee will be hosting a live stream of the swearing-in ceremony starting at 11:30 a.m. ET, as well as live video of the inaugural parade and the Commander-in-Chief's Ball.

• The Wall Street Journal will be presenting the inauguration live at 11 a.m ET. It will be anchored by Washington bureau chief Gerald F. Seib, Wendy Bounds and Simon Constable from its New York studios. You can watch it on multiple platforms including WSJ Live, YouTube, Hulu, and Ustream.

• CBS News, our sister site, will be offering live coverage on TV and the Web starting at 10 a.m. ET. The site will also feature live coverage of related events, interactive slide shows, and analysis of Obama's first term and what's ahead in his next term.

• NBCNews.com and the NBC Politics app, which is available on the iPhone, iPad, or iPod Touch, will carry live streams of NBC News' coverage starting at 10 a.m. ET.

• C-SPAN's online live coverage of the inauguration starts at 7 a.m. ET and will include the swearing in, followed by the president's address, the inaugural luncheon, and the inaugural parade.

• Fox News will offer a live stream of the inaugural address as well as coverage of related events around Washington. Fox's coverage will also be available on Hulu.

• ABC News and Yahoo News have teamed up to produce three feeds of online video coverage across ABCNews.com, Yahoo News, GoodMorningAmerica.com, ABC News' iPad and iPhone apps and ABC News affiliate websites, as well as on the ABC News YouTube channel.

Read More..

Attack at Algeria Gas Plant Heralds New Risks for Energy Development

The siege by Islamic militants at a remote Sahara desert natural gas plant in Algeria this week signaled heightened dangers in the region for international oil companies, at a time when they have been expanding operations in Africa as one of the world's last energy frontiers. (See related story: "Pictures: Four New Offshore Drilling Frontiers.")

As BP, Norway's Statoil, Italy's Eni, and other companies evacuated personnel from Algeria, it was not immediately clear how widely the peril would spread in the wake of the hostage-taking at the sprawling In Amenas gas complex near the Libyan border.

Map by National Geographic

Algeria, the fourth-largest crude oil producer on the continent and a major exporter of natural gas and refined fuels, may not have been viewed as the most hospitable climate for foreign energy companies, but that was due to unfavorable financial terms, bureaucracy, and corruption. The energy facilities themselves appeared to be safe, with multiple layers of security provided both by the companies and by government forces, several experts said. (See related photos: "Oil States: Are They Stable? Why It Matters.")

"It is particularly striking not only because it hasn't happened before, but because it happened in Algeria, one of the stronger states in the region," says Hanan Amin-Salem, a senior manager at the industry consulting firm PFC Energy, who specializes in country risk. She noted that in the long civil war that gripped the country throughout the 1990s, there had never been an attack on Algeria's energy complex. But now, hazard has spread from weak surrounding states, as the assault on In Amenas was carried out in an apparent retaliation for a move by French forces against the Islamists who had taken over Timbuktu and other towns in neighboring Mali. (See related story: "Timbuktu Falls.")

"What you're really seeing is an intensification of the fundamental problem of weak states, and empowerment of heavily armed groups that are really well motivated and want to pursue a set of aims," said Amin-Salem. In PFC Energy's view, she says, risk has increased in Mauritania, Chad, and Niger—indeed, throughout Sahel, the belt that bisects North Africa, separating the Sahara in the north from the tropical forests further south.

On Thursday, the London-based corporate consulting firm Exclusive Analysis, which was recently acquired by the global consultancy IHS, sent an alert to clients warning that oil and gas facilities near the Libyan and Mauritanian borders and in Mauritania's Hodh Ech Chargui province were at "high risk" of attack by jihadis.

"A Hot Place to Drill"

The attack at In Amenas comes at a time of unprecedented growth for the oil industry in Africa. (See related gallery: "Pictures: The Year's Most Overlooked Energy Stories.") Forecasters expect that oil output throughout Africa will double by 2025, says Amy Myers Jaffe, executive director of the energy and sustainability program at the University of California, Davis, who has counted 20 rounds of bidding for new exploration at sites in Africa's six largest oil-producing states.

Oil and natural gas are a large part of the Algerian economy, accounting for 60 percent of government budget revenues, more than a third of GDP and more than 97 percent of its export earnings. But the nation's resources are seen as largely undeveloped, and Algeria has tried to attract new investment. Over the past year, the government has sought to reform the law to boost foreign companies' interests in their investments, although those efforts have foundered.

Technology has been one of the factors driving the opening up of Africa to deeper energy exploration. Offshore and deepwater drilling success in the Gulf of Mexico and Brazil led to prospecting now under way offshore in Ghana, Mozambique, and elsewhere. (See related story: "New Oil—And a Huge Challenge—for Ghana.") Jaffe says the Houston-based company Anadarko Petroleum has sought to transfer its success in "subsalt seismic" exploration technology, surveying reserves hidden beneath the hard salt layer at the bottom of the sea, to the equally challenging seismic exploration beneath the sands of the Sahara in Algeria, where it now has three oil and gas operations.

Africa also is seen as one of the few remaining oil-rich regions of the world where foreign oil companies can obtain production-sharing agreements with governments, contracts that allow them a share of the revenue from the barrels they produce, instead of more limited service contracts for work performed.

"You now have the technology to tap the resources more effectively, and the fiscal terms are going to be more attractive than elsewhere—you put these things together and it's been a hot place to drill," says Jaffe, who doesn't see the energy industry's interest in Africa waning, despite the increased terrorism risk. "What I think will happen in some of these countries is that the companies are going to reveal new securities systems and procedures they have to keep workers safe," she says. "I don't think they will abandon these countries."

This story is part of a special series that explores energy issues. For more, visit The Great Energy Challenge.

Read More..

Sasha's View: 'Good Job, Daddy. You Didn't Mess Up'

President Barack Obama and Vice President Joe Biden today officially embarked on their second term, taking the Constitutionally mandated oath of office in two separate private ceremonies inside their homes.

Shortly before noon in the Blue Room of the White House, Obama raised his right hand, with his left on a family Bible, reciting the oath administrated by Chief Justice John Roberts. He was surrounded by immediate family members, including first lady Michelle Obama and daughters, Malia and Sasha.

As he hugged his wife and daughters, Sasha said, "Good job, Daddy."

"I did it," he said.

"You didn't mess up," she answered.

Biden was sworn in earlier today by Justice Sonia Sotomayor, the first Hispanic to administer a presidential oath, in a ceremony at his official residence at the U.S. Naval Observatory. He was joined by more than 120 guests, including cabinet members, extended family and his wife, Dr. Jill Biden.

Because Jan. 20 -- the official date for a new presidential term -- falls on a Sunday this year, organizers delayed by one day the traditional public inauguration ceremony and parade down Pennsylvania Avenue.

Vice President Joe Biden Sworn in for 2nd Term Watch Video

Obama Sworn In for Second Term, Kicks off Inaugural Festivities Watch Video

Obama and Biden will each repeat the oath on Monday on the west front of the Capitol, surrounded by hundreds of dignitaries and members of Congress. An estimated 800,000 people are expected to gather on the National Mall to witness the moment and inaugural parade to follow.

The dual ceremonies in 2013 means Obama will become the second president in U.S. history to take the presidential oath four times. He was sworn in twice in 2008 out of an abundance of caution after Roberts flubbed the oath of office during the public administration. This year Roberts read from a script.

Franklin Roosevelt was also sworn in four times but, unlike Obama, he was elected four times.

This year will mark the seventh time a president has taken the oath on a Sunday and then again on Monday for ceremonial purposes. Reagan last took the oath on a Sunday in 1985.

Both Obama and Biden took the oath using a special family Bible. Obama used a text that belonged to Michelle Obama's grandmother LaVaughn Delores Robinson. Biden placed his hand on a 120-year-old book with a Celtic cross on the cover that has been passed down through Biden clan.

The official inaugural activities today also included moments of prayer and remembrance that marked the solemnity of the day.

Obama and Biden met at Arlington National Cemetery for a brief morning ceremony to place a wreath on the Tomb of the Unknowns, honoring military service members who served and sacrificed. The men stood shoulder to shoulder, bowing their heads as a bugler played "Taps."

Biden, who is Catholic, began the day with a private family mass at his residence. The president and first family attended church services at Metropolitan African Methodist Episcopal Church, a historically black church and site of two pre-inaugural prayer services for former President Bill Clinton and Vice President Al Gore and their families.

The Obamas and Bidens plan to participate in a church service on Monday morning at St. John's Episcopal, across Lafayette Park from the White House. They will also attend a National Prayer Service on Tuesday at the National Cathedral.

Later on Sunday evening, the newly-inaugurated leaders will attend a candlelight reception at the National Building Museum. The president and vice president are expected to deliver brief remarks to their supporters.

Read More..

Earth may be crashing through dark matter walls

Earth is constantly crashing through huge walls of dark matter, and we already have the tools to detect them. That's the conclusion of physicists who say the universe may be filled with a patchwork quilt of force fields created shortly after the big bang.

Observations of how mass clumps in space suggest that about 86 per cent of all matter is invisible dark matter, which interacts with ordinary matter mainly through gravity. The most popular theory is that dark matter is made of weakly interacting massive particles.

WIMPs should also interact with ordinary matter via the weak nuclear force, and their presence should have slight but measurable effects. However, years of searches for WIMPs have been coming up empty.

"So far nothing is found, and I feel like it's time to broaden the scope of our search," says Maxim Pospelov of the University of Victoria in Canada. "What we propose is to look for some other signatures."

Bubbly cosmos

Pospelov and colleagues have been examining a theory that at least some of the universe's dark matter is tied up in structures called domain walls, akin to the boundaries between tightly packed bubbles. The idea is that the hot early universe was full of an exotic force field that varied randomly. As the universe expanded and cooled, the field froze, leaving a patchwork of domains, each with its own distinct value for the field.

Having different fields sit next to each other requires energy to be stored within the domain walls. Mass and energy are interchangeable, so on a large scale a network of domain walls can look like concentrations of mass – that is, like dark matter, says Pospelov.

If the grid of domain walls is packed tightly enough – say, if the width of the domains is several hundred times the distance between Earth and the sun – Earth should pass through a domain wall once every few years. "As a human, you wouldn't feel a thing," says Pospelov. "You will go through the wall without noticing." But magnetometers – devices that, as the name suggests, measure magnetic fields – could detect the walls, say Pospelov and colleagues in a new study. Although the field inside a domain would not affect a magnetometer, the device would sense the change when Earth passes through a domain wall.

Dark matter walls have not been detected yet because anyone using a single magnetometer would find the readings swamped by noise, Pospelov says. "You'd never be able to say if it's because the Earth went through a bizarre magnetic field or if a grad student dropped their iPhone or something," he says.

Network needed

Finding the walls will require a network of at least five detectors spread around the world, Pospelov suggests. Colleagues in Poland and California have already built one magnetometer each and have shown that they are sensitive enough for the scheme to work.

Domain walls wouldn't account for all the dark matter in the universe, but they could explain why finding particles of the stuff has been such a challenge, says Pospelov.

If domain walls are found, the news might come as a relief to physicists still waiting for WIMPs to show up. Earlier this month, for instance, a team working with a detector in Russia that has been running for more than 24 years announced that they have yet to see any sign of these dark matter candidates.

Douglas Finkbeiner of the Harvard-Smithsonian Center for Astrophysics, who was not involved in Pospelov's study, isn't yet convinced that dark matter walls exist. But he is glad that physicists are keeping an open mind about alternatives to WIMPs.

"We've looked for WIMP dark matter in so many ways," he says. "At some point you have to ask, are we totally on the wrong track?"

Journal reference: Physical Review Letters, DOI: 10.1103/PhysRevLett.110.021803

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

Read More..

10 Japanese unaccounted for in Algeria crisis

TOKYO: A Japanese engineering firm said Sunday that 10 Japanese and seven foreign workers remained unaccounted for at an Algerian gas plant that was seized by Islamist militants.

JGC Corp. said it had confirmed the safety of 61 of 78 workers after Algerian troops stormed the remote gas plant Saturday to end the hostage crisis that killed 23 foreigners and Algerians.

"We have newly confirmed the safety of 41 of our workers but the safety of the remaining 10 Japanese and seven foreign workers is yet to be confirmed," JGC spokesman Takeshi Endo told reporters.

- AFP/ck

Read More..

Microsoft blazes trail to next PC

Microsoft Surface Pro: the design isn't perfect, but the fact that it can function as a standalone tablet and is thin and light puts it ahead of the convertible-laptop pack.

(Credit:
CNET)

PC makers take note. Microsoft is pioneering the next PC.

Here are two simple reasons why the Surface Pro makes a good case as the template for the new PC. One, Microsoft realized that the device's electronics should go behind the glass, not under the keyboard. Two, the device uses a real processor.

Let's address the electronics first. Most of the newfangled laptops I saw at
CES were convertibles. That is, the displays are not detachable because the core electronics are under the keyboard, just like your father's laptop.

And most of them were unimpressive. The mechanics necessary to flip and/or slide the screen and convert the laptop to
tablet mode were more often than not kludgy and some seemed destined for mechanical problems down the pike.

And the more problematic designs weren't thin or light, either. At least not when compared with popular tablets like Apple's
iPad or Google's Nexus.

One of the few exceptions -- as I noted before -- was the HP EliteBook Revolve. That 11.6-inch design was about as well conceived as a convertible can be.

But there's a reason for that: HP has been building Windows convertibles for ages. The EliteBook 2700 series has been around since the dawn of Windows XP. So, HP has this down to a science.

But, again, that's a rare exception at present. The future leans more toward a PC with the electronics behind the glass. And there's no better example right now than the Surface Pro.

Microsoft was bold enough to go with a mainstream third-generation Core Intel "Ivy Bridge" chip, not the slower Atom processor that most Windows 8 tablet and detachable makers have opted for.

Yeah, the battery life won't be great, but Microsoft, I think, knew (rightly so) that it would be crucified if it opted for the performance-challenged Atom chip, which isn't up to the task of running serious desktop applications on Windows 8.

Remember the netbook? That's one way to look at the first crop of Atom-based Windows 8 tablets: a netbook in tablet clothing. Microsoft didn't want to go there.

And give Lenovo some credit too. It showed off the ThinkPad Helix detachable at CES that separates from the base to become a full-fledged Ivy Bridge-based tablet, not unlike the Microsoft Surface Pro.

And Intel, I think, in its heart of hearts knows Atom isn't really up to the task. Thus, the revelation at CES of the most power-efficient Ivy Bridge yet. One of Intel's goals is to get these new Ivy Bridge chips -- as well as upcoming "Haswell" chips -- behind the glass, as Intel's Adam King told me at CES.

So, I would expect to see an increasing number of Windows 8 tablets and/or detachables sporting Intel's mainstream Haswell Core processors later this year.

And battery life will improve with Haswell. I would be fine with a Windows 8 tablet packing a real Intel chip that gets six hours of battery life. And a Haswell-based Surface tablet should meet or exceed this.

Sony Vaio Duo 11 convertible: The apparatus to support the display in tablet mode isn't exactly elegant.

(Credit:
CNET)

Read More..

Attack at Algeria Gas Plant Heralds New Risks for Energy Development

The siege by Islamic militants at a remote Sahara desert natural gas plant in Algeria this week signaled heightened dangers in the region for international oil companies, at a time when they have been expanding operations in Africa as one of the world's last energy frontiers. (See related story: "Pictures: Four New Offshore Drilling Frontiers.")

As BP, Norway's Statoil, Italy's Eni, and other companies evacuated personnel from Algeria, it was not immediately clear how widely the peril would spread in the wake of the hostage-taking at the sprawling In Amenas gas complex near the Libyan border.

Map by National Geographic

Algeria, the fourth-largest crude oil producer on the continent and a major exporter of natural gas and refined fuels, may not have been viewed as the most hospitable climate for foreign energy companies, but that was due to unfavorable financial terms, bureaucracy, and corruption. The energy facilities themselves appeared to be safe, with multiple layers of security provided both by the companies and by government forces, several experts said. (See related photos: "Oil States: Are They Stable? Why It Matters.")

"It is particularly striking not only because it hasn't happened before, but because it happened in Algeria, one of the stronger states in the region," says Hanan Amin-Salem, a senior manager at the industry consulting firm PFC Energy, who specializes in country risk. She noted that in the long civil war that gripped the country throughout the 1990s, there had never been an attack on Algeria's energy complex. But now, hazard has spread from weak surrounding states, as the assault on In Amenas was carried out in an apparent retaliation for a move by French forces against the Islamists who had taken over Timbuktu and other towns in neighboring Mali. (See related story: "Timbuktu Falls.")

"What you're really seeing is an intensification of the fundamental problem of weak states, and empowerment of heavily armed groups that are really well motivated and want to pursue a set of aims," said Amin-Salem. In PFC Energy's view, she says, risk has increased in Mauritania, Chad, and Niger—indeed, throughout Sahel, the belt that bisects North Africa, separating the Sahara in the north from the tropical forests further south.

On Thursday, the London-based corporate consulting firm Exclusive Analysis, which was recently acquired by the global consultancy IHS, sent an alert to clients warning that oil and gas facilities near the Libyan and Mauritanian borders and in Mauritania's Hodh Ech Chargui province were at "high risk" of attack by jihadis.

"A Hot Place to Drill"

The attack at In Amenas comes at a time of unprecedented growth for the oil industry in Africa. (See related gallery: "Pictures: The Year's Most Overlooked Energy Stories.") Forecasters expect that oil output throughout Africa will double by 2025, says Amy Myers Jaffe, executive director of the energy and sustainability program at the University of California, Davis, who has counted 20 rounds of bidding for new exploration at sites in Africa's six largest oil-producing states.

Oil and natural gas are a large part of the Algerian economy, accounting for 60 percent of government budget revenues, more than a third of GDP and more than 97 percent of its export earnings. But the nation's resources are seen as largely undeveloped, and Algeria has tried to attract new investment. Over the past year, the government has sought to reform the law to boost foreign companies' interests in their investments, although those efforts have foundered.

Technology has been one of the factors driving the opening up of Africa to deeper energy exploration. Offshore and deepwater drilling success in the Gulf of Mexico and Brazil led to prospecting now under way offshore in Ghana, Mozambique, and elsewhere. (See related story: "New Oil—And a Huge Challenge—for Ghana.") Jaffe says the Houston-based company Anadarko Petroleum has sought to transfer its success in "subsalt seismic" exploration technology, surveying reserves hidden beneath the hard salt layer at the bottom of the sea, to the equally challenging seismic exploration beneath the sands of the Sahara in Algeria, where it now has three oil and gas operations.

Africa also is seen as one of the few remaining oil-rich regions of the world where foreign oil companies can obtain production-sharing agreements with governments, contracts that allow them a share of the revenue from the barrels they produce, instead of more limited service contracts for work performed.

"You now have the technology to tap the resources more effectively, and the fiscal terms are going to be more attractive than elsewhere—you put these things together and it's been a hot place to drill," says Jaffe, who doesn't see the energy industry's interest in Africa waning, despite the increased terrorism risk. "What I think will happen in some of these countries is that the companies are going to reveal new securities systems and procedures they have to keep workers safe," she says. "I don't think they will abandon these countries."

This story is part of a special series that explores energy issues. For more, visit The Great Energy Challenge.

Read More..

Algeria Hostage Crisis Over, One American Dead

After the Algerian military's final assault on terrorists holding hostages at a gas complex, the four-day hostage crisis is over, but apparently with additional loss of life among the foreign hostages.

One American, Fred Buttaccio of Texas, has been confirmed dead by the U.S. State Department. Two more U.S. hostages remain unaccounted for, with growing concern among U.S. officials that they did not survive.

But another American, Mark Cobb of Corpus Christi, Texas is now confirmed as safe. Sources close to his family say Cobb, who is a senior manager of the facility, is safe and reportedly sent a text message " I'm alive."

Inside Algerian Hostage Crisis, One American Dead Watch Video

American Hostages Escape From Algeria Terrorists Watch Video

In a statement, President Obama said, "Today, the thoughts and prayers of the American people are with the families of all those who were killed and injured in the terrorist attack in Algeria. The blame for this tragedy rests with the terrorists who carried it out, and the United States condemns their actions in the strongest possible terms. ... This attack is another reminder of the threat posed by al Qaeda and other violent extremist groups in North Africa."

According to Algerian state media, 32 militants are dead and a total of 23 hostages perished during the four-day siege of the In Amenas facility in the Sahara. The Algerian Interior Ministry also says 107 foreign nationals who worked at the facility for BP and other firms were rescued or escaped from the al Qaeda-linked terrorists who took over the BP joint venture facility on Wednesday.

The Japanese government says it fears "very grave" news, with multiple casualties among the 10 Japanese citizens working at the In Amenas gas plant.

Five British nationals and one U.K. resident are either deceased or unaccounted for in the country, according to British Foreign Minister William Hague. Hague also said that the Algerians have reported that they are still trying to clear boobytraps from the site.

Read More..